LOCUS       NM_152291               2467 bp    mRNA    linear   PRI 02-OCT-2011
DEFINITION  Homo sapiens mucin 7, secreted (MUC7), transcript variant 3, mRNA.
ACCESSION   NM_152291
VERSION     NM_152291.2  GI:222418644
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2467)
  AUTHORS   Heath,A.C., Whitfield,J.B., Martin,N.G., Pergadia,M.L., Goate,A.M.,
            Lind,P.A., McEvoy,B.P., Schrage,A.J., Grant,J.D., Chou,Y.L.,
            Zhu,R., Henders,A.K., Medland,S.E., Gordon,S.D., Nelson,E.C.,
            Agrawal,A., Nyholt,D.R., Bucholz,K.K., Madden,P.A. and
            Montgomery,G.W.
  TITLE     A quantitative-trait genome-wide association study of alcoholism
            risk in the community: findings and implications
  JOURNAL   Biol. Psychiatry 70 (6), 513-518 (2011)
   PUBMED   21529783
REFERENCE   2  (bases 1 to 2467)
  AUTHORS   Carrara,S., Cangi,M.G., Arcidiacono,P.G., Perri,F., Petrone,M.C.,
            Mezzi,G., Boemo,C., Talarico,A., Cin,E.D., Grassini,G., Doglioni,C.
            and Testoni,P.A.
  TITLE     Mucin expression pattern in pancreatic diseases: findings from
            EUS-guided fine-needle aspiration biopsies
  JOURNAL   Am. J. Gastroenterol. 106 (7), 1359-1363 (2011)
   PUBMED   21647207
  REMARK    GeneRIF: MUC7 expression in ductal adenocarcinoma (DAC) and chronic
            pancreatitis was not statistically significant, but MUC7 could be
            considered as potential marker of malignant lesions, especially in
            pancreatic DAC, as it was positive in 73% of these cases.
REFERENCE   3  (bases 1 to 2467)
  AUTHORS   Han,S., Lan,Q., Park,A.K., Lee,K.M., Park,S.K., Ahn,H.S.,
            Shin,H.Y., Kang,H.J., Koo,H.H., Seo,J.J., Choi,J.E., Ahn,Y.O.,
            Chanock,S.J., Kim,H., Rothman,N. and Kang,D.
  TITLE     Polymorphisms in innate immunity genes and risk of childhood
            leukemia
  JOURNAL   Hum. Immunol. 71 (7), 727-730 (2010)
   PUBMED   20438785
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 2467)
  AUTHORS   Schuurhof,A., Bont,L., Siezen,C.L., Hodemaekers,H., van
            Houwelingen,H.C., Kimman,T.G., Hoebee,B., Kimpen,J.L. and
            Janssen,R.
  TITLE     Interleukin-9 polymorphism in infants with respiratory syncytial
            virus infection: an opposite effect in boys and girls
  JOURNAL   Pediatr. Pulmonol. 45 (6), 608-613 (2010)
   PUBMED   20503287
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2467)
  AUTHORS   Habte,H.H., de Beer,C., Lotz,Z.E., Roux,P. and Mall,A.S.
  TITLE     Anti-HIV-1 activity of salivary MUC5B and MUC7 mucins from HIV
            patients with different CD4 counts
  JOURNAL   Virol. J. 7, 269 (2010)
   PUBMED   20946627
  REMARK    GeneRIF: MUC5B and MUC7 from HIV patients, unlike the MUC5B and
            MUC7 from HIV negative individuals, did not inhibit HIV-1 activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2467)
  AUTHORS   Kirkbride,H.J., Bolscher,J.G., Nazmi,K., Vinall,L.E., Nash,M.W.,
            Moss,F.M., Mitchell,D.M. and Swallow,D.M.
  TITLE     Genetic polymorphism of MUC7: allele frequencies and association
            with asthma
  JOURNAL   Eur. J. Hum. Genet. 9 (5), 347-354 (2001)
   PUBMED   11378823
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2467)
  AUTHORS   Prakobphol,A., Thomsson,K.A., Hansson,G.C., Rosen,S.D.,
            Singer,M.S., Phillips,N.J., Medzihradszky,K.F., Burlingame,A.L.,
            Leffler,H. and Fisher,S.J.
  TITLE     Human low-molecular-weight salivary mucin expresses the sialyl
            lewisx determinant and has L-selectin ligand activity
  JOURNAL   Biochemistry 37 (14), 4916-4927 (1998)
   PUBMED   9538010
REFERENCE   8  (bases 1 to 2467)
  AUTHORS   Troxler,R.F., Iontcheva,I., Oppenheim,F.G., Nunes,D.P. and
            Offner,G.D.
  TITLE     Molecular characterization of a major high molecular weight mucin
            from human sublingual gland
  JOURNAL   Glycobiology 7 (7), 965-973 (1997)
   PUBMED   9363439
REFERENCE   9  (bases 1 to 2467)
  AUTHORS   Bobek,L.A., Liu,J., Sait,S.N., Shows,T.B., Bobek,Y.A. and
            Levine,M.J.
  TITLE     Structure and chromosomal localization of the human salivary mucin
            gene, MUC7
  JOURNAL   Genomics 31 (3), 277-282 (1996)
   PUBMED   8838308
REFERENCE   10 (bases 1 to 2467)
  AUTHORS   Bobek,L.A., Tsai,H., Biesbrock,A.R. and Levine,M.J.
  TITLE     Molecular cloning, sequence, and specificity of expression of the
            gene encoding the low molecular weight human salivary mucin (MUC7)
  JOURNAL   J. Biol. Chem. 268 (27), 20563-20569 (1993)
   PUBMED   7690757
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB206328.1, L13283.1 and
            BC025688.1.
            On Feb 3, 2009 this sequence version replaced gi:22748664.
            
            Summary: This gene encodes a small salivary mucin, which is thought
            to play a role in facilitating the clearance of bacteria in the
            oral cavity and to aid in mastication, speech, and swallowing. The
            central domain of this glycoprotein contains tandem repeats, each
            composed of 23 amino acids. The most common allele contains 6
            repeats, and some alleles may be associated with susceptibility to
            asthma. Alternatively spliced transcript variants with different 5'
            UTR, but encoding the same protein, have been found for this
            gene.[provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (3) represents the shortest
            transcript and has a different 5' UTR compared to transcript
            variant 1. Transcript variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-566               DB206328.1         1-566
            567-1656            L13283.1           473-1562
            1657-2467           BC025688.1         1555-2365
FEATURES             Location/Qualifiers
     source          1..2467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..2467
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /note="mucin 7, secreted"
                     /db_xref="GeneID:4589"
                     /db_xref="HGNC:7518"
                     /db_xref="HPRD:11759"
                     /db_xref="MIM:158375"
     exon            1..175
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /inference="alignment:Splign"
                     /number=3a
     misc_feature    149..151
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /note="upstream in-frame stop codon"
     exon            176..244
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /inference="alignment:Splign"
                     /number=4
     CDS             191..1324
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /note="mucin 7, salivary; mucin-7; MUC-7; apo-MG2;
                     salivary mucin-7"
                     /codon_start=1
                     /product="mucin-7 precursor"
                     /protein_id="NP_689504.2"
                     /db_xref="GI:222418645"
                     /db_xref="CCDS:CCDS3541.1"
                     /db_xref="GeneID:4589"
                     /db_xref="HGNC:7518"
                     /db_xref="HPRD:11759"
                     /db_xref="MIM:158375"
                     /translation="MKTLPLFVCICALSACFSFSEGRERDHELRHRRHHHQSPKSHFE
                     LPHYPGLLAHQKPFIRKSYKCLHKRCRPKLPPSPNNPPKFPNPHQPPKHPDKNSSVVN
                     PTLVATTQIPSVTFPSASTKITTLPNVTFLPQNATTISSRENVNTSSSVATLAPVNSP
                     APQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTP
                     PATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASA
                     PPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAPTHQTT
                     TSVTTQTTTTKQPTSAPGQNKISRFLLYMKNLLNRIIDDMVEQ"
     sig_peptide     191..256
                     /gene="MUC7"
                     /gene_synonym="MG2"
     mat_peptide     257..1321
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /product="mucin-7"
     misc_feature    683..751
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="1; propagated from UniProtKB/Swiss-Prot (Q8TAX7.2);
                     Region: Repetitive region"
     misc_feature    752..820
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="2; propagated from UniProtKB/Swiss-Prot (Q8TAX7.2);
                     Region: Repetitive region"
     misc_feature    821..889
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="3; propagated from UniProtKB/Swiss-Prot (Q8TAX7.2);
                     Region: Repetitive region"
     misc_feature    890..958
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="4; propagated from UniProtKB/Swiss-Prot (Q8TAX7.2);
                     Region: Repetitive region"
     misc_feature    959..1027
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="5; propagated from UniProtKB/Swiss-Prot (Q8TAX7.2);
                     Region: Repetitive region"
     misc_feature    1028..1096
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="6; propagated from UniProtKB/Swiss-Prot (Q8TAX7.2);
                     Region: Repetitive region"
     exon            245..2443
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /inference="alignment:Splign"
                     /number=5
     polyA_signal    2419..2424
                     /gene="MUC7"
                     /gene_synonym="MG2"
     polyA_site      2443
                     /gene="MUC7"
                     /gene_synonym="MG2"
ORIGIN      
        1 ttatcttaaa tctaatagat ttcctatttc caaaaagctc gactggagtg ttataaaacc
       61 tgaaaattct cttgtgcttt ctcttctttt gcttctagtt accatcctca aaggattggc
      121 taaaagcaag caactggatt gaacacccta agaagaaaga ttcacactgc accaggagac
      181 atcagaaaga atgaaaactc tgccgctgtt tgtgtgcatc tgtgcactga gtgcttgctt
      241 ctcgttcagt gaaggtcgag aaagggatca tgaactacgt cacagaaggc atcatcacca
      301 atcacccaaa tctcactttg aattaccaca ttatcctgga ctgctagctc accagaagcc
      361 gttcattaga aagtcctata aatgtctgca caaacgctgt aggcctaagc ttccaccttc
      421 acctaataac ccccccaaat tcccaaatcc tcaccagcca cctaaacatc cagataaaaa
      481 tagcagtgtg gtcaacccta ccttagtggc tacaacccaa attccatctg tgactttccc
      541 atcagcttcc accaaaatta ctacccttcc aaatgtgact tttcttcccc agaatgccac
      601 caccatatct tcaagagaaa atgttaacac aagctcttct gtagctacat tagcaccagt
      661 gaattcccca gctccacaag acaccacagc tgccccaccc acaccttctg caactacacc
      721 agctccacca tcttcctcag ctccaccaga gaccacagct gccccaccca caccttctgc
      781 aactacacaa gctccaccat cttcctcagc tccaccagag accacagctg ccccacccac
      841 acctcctgca actacaccag ctccaccatc ttcctcagct ccaccagaga ccacagctgc
      901 cccacccaca ccttctgcaa ctacaccagc tccactatct tcctcagctc caccagagac
      961 cacagctgtc ccacccacac cttctgcaac taccctagac ccatcatccg cctcagctcc
     1021 accagagacc acagctgccc cacccacacc ttctgcaact acaccagctc caccgtcttc
     1081 cccagctcca caagagacca cagctgcccc aattaccaca cctaattctt ccccaactac
     1141 tcttgcacct gacacttctg aaacttcagc tgcacccaca caccagacta ctacttcggt
     1201 cactactcaa actactacta ctaaacaacc aacttcagct cctggccaaa ataaaatttc
     1261 tcgatttctt ttatatatga agaatctact aaacagaatt attgacgaca tggtggagca
     1321 atagtatatt gtatgttgta aagtgttctg tcatttacaa gatgtgattc atgagtgcag
     1381 aactaccacc tttcttttag caccaatccc aacatgaaat tatattactc agatttaaag
     1441 cactatcatt aatctttcaa tctaattatt caccaccaca agacctatta acaagacaaa
     1501 atgcctctat cccacaagcc agatgcaggt ctggggttca aaataactct ttggatccta
     1561 cagagatagc ctactgaggg caaagaaagt ccttagataa agagagaata ttgtatgggc
     1621 catcaaccat ttacttttcc ctgaatgtta gaaactacaa aaccactacc ttgtaccccc
     1681 atcaaaatcc cacctgaacc atctaatcct ataaacataa aggggtaaaa ttggaactct
     1741 ccagatgaac aaagacatct aaatatctgt agatagaaac atttatctat ctaaatatat
     1801 tgatagacct gtcattgtat tgattaatga caaaaccctt tagataatta tcttccattt
     1861 taaataaaat tttatttcac aaatatgagc caagaaagag gaaagttgat ttgaagtgag
     1921 gattagaagt gaatgacaat aaagtctggc agccaagcac gaaccaagac tggcactatt
     1981 tttcttagtg tatataattg tttaaactgc aaggttgaca tttattgtgt tgtgtctaag
     2041 ttaatttcga tctaatgtac ctgattctag cctctgtgaa caacaagaat atgtttgtgt
     2101 atgttcacat ggtgcttata atatttcact atcaattcaa ttaattcaca taaattccat
     2161 gtgaaatgta ttcaacaatg gaatattttc taaaacattt agtatacatt tgaatgtatt
     2221 ttaaaccatg ccaaactact gctttaatgt caagtttgca gaattgtctc tgaaaataaa
     2281 aaccctgact ttagttgtaa aacaataaaa gttagctact tggtatacgg agatgttaat
     2341 ttgggatatg gaggcatttt tatcttctgt cactactact taaaactctg atgattatgt
     2401 tagatttttt tgctaactaa taaagatttc aaatggcaat ttaaaaaaaa aaaaaaaaaa
     2461 aaaaaaa
//

